Apart from, you know, not actually getting the job.

The worst thing about applying for positions–permanent, temporary, full time, part time, attractive, repellent–is that in doing one’s damnedest to convince the search committee that one is right for the job, one has a way of convincing oneself, which makes the (almost guaranteed) rejection far more of a blow than it would have been otherwise.  Being hoisted by one’s own petard, so to speak.